Atmospheric effects and spurious signals in GPS analyses

Improvements in the analyses of Global Positioning System (GPS) observations yield resolvable millimeter to submillimeter differences in coordinate estimates, thus providing sufficient resolution to distinguish subtle differences in analysis methodologies. Here we investigate the effects on site coordinates of using different approaches to modeling atmospheric loading deformation (ATML) and handling of tropospheric delays. The rigorous approach of using the time-varying Vienna Mapping Function 1 yields solutions with lower noise at a range of frequencies compared with solutions generated using empirical mapping functions. This is particularly evident when ATML is accounted for. Some improvement also arises from using improved a priori zenith hydrostatic delays (ZHD), with the combined effect being site-specific. Importantly, inadequacies in both mapping functions and a priori ZHDs not only introduce time-correlated noise but significant periodic terms at solar annual and semiannual periods. We find no significant difference between solutions where nontidal ATML is applied at the observation level rather than as a daily averaged value, but failing to model diurnal and semidiurnal tidal ATML at the observation level can introduce anomalous propagated signals with periods that closely match the GPS draconitic annual (∼351.4 days) and semiannual period (∼175.7 days). Exacerbated by not fixing ambiguities, these signals are evident in both stacked and single-site power spectra, with each tide contributing roughly equally to the dominant semiannual peak. The amplitude of the propagated signal reaches a maximum of 0.8 mm with a clear latitudinal dependence that is not correlated directly with locations of maximum tidal amplitude.Australian Research Council’s Discovery Project

How to Measure Group Selection in Real-world Populations

Multilevel selection and the evolution of cooperation are fundamental to the formation of higher-level organisation and the evolution of biocomplexity, but such notions are controversial and poorly understood in natural populations. The theoretic principles of group selection are well developed in idealised models where a population is neatly divided into multiple semi-isolated sub-populations. But since such models can be explained by individual selection given the localised frequency-dependent effects involved, some argue that the group selection concepts offered are, even in the idealised case, redundant and that in natural conditions where groups are not well-defined that a group selection framework is entirely inapplicable. This does not necessarily mean, however, that a natural population is not subject to some interesting localised frequency-dependent effects – but how could we formally quantify this under realistic conditions? Here we focus on the presence of a Simpson’s Paradox where, although the local proportion of cooperators decreases at all locations, the global proportion of cooperators increases. We illustrate this principle in a simple individual-based model of bacterial biofilm growth and discuss various complicating factors in moving from theory to practice of measuring group selection

Roche tomography of cataclysmic variables - V. A high-latitude star-spot on RU Pegasi

We present Roche tomograms of the secondary star in the dwarf nova system RU Pegasi derived from blue and red arm ISIS data taken on the 4.2-m William Herschel Telescope. We have applied the entropy landscape technique to determine the system parameters and obtained component masses of M1 = 1.06 Msun, M2 = 0.96 Msun, an orbital inclination angle of i = 43 degrees, and an optimal systemic velocity of gamma = 7 km/s. These are in good agreement with previously published values. Our Roche tomograms of the secondary star show prominent irradiation of the inner Lagrangian point due to illumination by the disc and/or bright spot, which may have been enhanced as RU Peg was in outburst at the time of our observations.We find that this irradiation pattern is axi-symmetric and confined to regions of the star which have a direct view of the accretion regions. This is in contrast to previous attempts to map RU Peg which suggested that the irradiation pattern was non-symmetric and extended beyond the terminator. We also detect additional inhomogeneities in the surface distribution of stellar atomic absorption that we ascribe to the presence of a large star-spot. This spot is centred at a latitude of about 82 degrees and covers approximately 4 per cent of the total surface area of the secondary. In keeping with the high latitude spots mapped on the cataclysmic variables AE Aqr and BV Cen, the spot on RU Peg also appears slightly shifted towards the trailing hemisphere of the star. Finally, we speculate that early mapping attempts which indicated non-symmetric irradiation patterns which extended beyond the terminator of CV donors could possibly be explained by a superposition of symmetric heating and a large spot.Comment: 14 pages, 10 figures, 3 tables Accepted for publication in Monthly Notices of the Royal Astronomical Societ

Rhythms of Locomotion Expressed by Limulus polyphemus, the American Horseshoe Crab: II. Relationship to Circadian Rhythms of Visual Sensitivity

In the laboratory, horseshoe crabs express a circadian rhythm of visual sensitivity as well as daily and circatidal rhythms of locomotion. The major goal of this investigation was to determine whether the circadian clock underlying changes in visual sensitivity also modulates locomotion. To address this question, we developed a method for simultaneously recording changes in visual sensitivity and locomotion. Although every animal (24) expressed consistent circadian rhythms of visual sensitivity, rhythms of locomotion were more variable: 44% expressed a tidal rhythm, 28% were most active at night, and the rest lacked statistically significant rhythms. When exposed to artificial tides, 8 of 16 animals expressed circatidal rhythms of locomotion that continued after tidal cycles were stopped. However, rhythms of visual sensitivity remained stable and showed no tendency to be influenced by the imposed tides or locomotor activity. These results indicate that horseshoe crabs possess at least two biological clocks: one circadian clock primarily used for modulating visual sensitivity, and one or more clocks that control patterns of locomotion. This arrangement allows horseshoe crabs to see quite well while mating during both daytime and nighttime high tides

Brain structural connectivity and neurodevelopment in post-Fontan adolescents

Congenital heart disease (CHD) is the most common congenital anomaly, with single ventricle (SV) defects accounting for nearly 10% of all CHD. SV defects tend to be the most severe forms of CHD: all patients born with SV require multiple open heart surgeries, often beginning in the neonatal period, ultimately leading to the Fontan procedure. Due to improvements in surgical procedures and medical care, more patients are surviving into adolescence and adulthood. Brain imaging and pathology studies have shown that patients with SV have differences in brain structure and metabolism even before the first surgery, and as early as in utero. Furthermore, a significant number of patients have new or more severe lesions after the initial surgery, and many still have brain abnormalities into early childhood. However, there are no detailed brain structural data of SV patients in adolescence. Our group recruited a large cohort of post-Fontan SV patients aged 10-19 years. Separate analyses of neuropsychological and behavioral outcomes in these patients show deficits in multiple areas of cognition, increased rates of attention deficit-hyperactivity disorder (ADHD), and increased use of remedial and/or special education services compared to a control group. Post-Fontan adolescents have more gross brain abnormalities, including evidence of chronic ischemic stroke. Furthermore, there are widespread reductions in cortical and subcortical gray matter volume and cortical thickness, some of which are associated with medical and surgical variables. Diffusion tensor imaging (DTI) analyses show widespread areas of altered white matter microstructure in deep subcortical and cerebellar white matter. In this dissertation, I use graph theory methods to characterize structural connectivity based on gray matter (cortical thickness covariance) and white matter (DTI tractography), and examine associations between brain structure and neurodevelopment. I found that brain network connectivity differs in post-Fontan patients compared with controls, both at the global and regional level. Additionally, deficits in overall network structure were associated with impaired neurodevelopment in several domains, including general intelligence, executive function, and visuospatial skills. These data suggest that early neuroprotection should be a major focus in the care of SV patients, with the goal of improving long-term neurodevelopmental outcomes

An Exploration of Traditional and Data Driven Predictors of Programming Performance

This thesis investigates factors that can be used to predict the success or failure of students taking an introductory programming course. Four studies were performed to explore how aspects of the teaching context, static factors based upon traditional learning theories, and data-driven metrics derived from aspects of programming behaviour were related to programming performance. In the first study, a systematic review into the worldwide outcomes of programming courses revealed an average pass rate of 67.7\%. This was found to have not significantly changed over time, or to have differed based upon aspects of the teaching context, such as the programming language taught to students. The second study showed that many of the factors based upon traditional learning theories, such as learning styles, are context dependent, and fail to consistently predict programming performance when they are applied across different teaching contexts. The third study explored data-driven metrics derived from the programming behaviour of students. Analysing data logged from students using the BlueJ IDE, 10 new data-driven metrics were identified and validated on three independently gathered datasets. Weaker students were found to make a greater percentage of successive errors, and spend a greater percentage of their lab time resolving errors than stronger students. The Robust Relative algorithm was developed to hybridize four of the strongest data-driven metrics into a performance predictor. The novel relative scoring of students based upon how their resolve times for different types of errors compared to the resolve times of their peers, resulted in a predictor which could explain a large proportion of the variance in the performance of three independent cohorts, $R^2$ = 42.19\%, 43.65\% and 44.17\% - almost double the variance which could be explained by Jadud's Error Quotient metric. The fourth study situated the findings of this thesis within the wider literature, by applying meta-analysis techniques to statistically synthesise fifty years of conflicting research, such that the most important factors for learning programming could be identified. 482 results describing the effects of 116 factors on programming performance were synthesised and consolidated to form a six class theoretical framework. The results showed that the strongest predictors identified over the past fifty years are data-driven metrics based upon programming behaviour. Several of the traditional predictors were also found to be influential, suggesting that both a certain level of scientific maturity and self-concept are necessary for programming. Two thirds of the weakest predictors were based upon demographic and psychological factors, suggesting that age, gender, self-perceived abilities, learning styles, and personality traits have no relevance for programming performance. This thesis argues that factors based upon traditional learning theories struggle to consistently predict programming performance across different teaching contexts because they were not intended to be applied for this purpose. In contrast, the main advantage of using data-driven approaches to derive metrics based upon students' programming processes, is that these metrics are directly based upon the programming behaviours of students, and therefore can encapsulate such changes in their programming knowledge over time. Researchers should continue to explore data-driven predictors in the future

Circatidal and Circadian Rhythms of Locomotion in Limulus polyphemus

The nocturnal increases in the sensitivity of the lateral eye of Limulus polyphemus, the species of horseshoe crab found along the Atlantic coast, have been firmly established as being controlled by an endogenous circadian clock (1,2,3) located in the brain (4). Virtually nothing is known, however, about the control of the animal’s behavioral rhythms of mating and spawning that are observed in the intertidal zone during high tides in late spring (5,6,7). Many other marine species, especially intertidal crabs, exhibit similar rhythmic behaviors that have been demonstrated to be under the control of endogenous clocks that are circatidal (8,9,10,11,12), circadian (10,12), or both. While there is some evidence that the activity of juvenile horseshoe crabs is primarily nocturnal (13,14), and possibly controlled by a circadian clock (14), we know of no published work showing that locomotor activity in the adult is endogenously controlled on either a 12.4-h (circatidal) or 24-h (circadian) basis. We report here that locomotor activity in adult individuals of L. polyphemus is endogenously modulated on both a circatidal and a circadian basis and that when the animals are subjected to a light-dark (LD) cycle, most activity occurs at night

Multi-epoch infrared photometry of the star forming region G173.58+2.45

We present a multi-epoch infrared photometric study of the intermediate-mass star forming region G173.58+2.45. Photometric observations are obtained using the near-infrared $JHKL'M'$ filters and narrow-band filters centered at the wavelengths of H$_2$ (1-0) S(1) (2.122 $\mu$m) and [FeII] (1.644 $\mu$m) lines. The H$_2$ image shows molecular emission from shocked gas, implying the presence of multiple star formation and associated outflow activity. We see evidence for several collimated outflows. The most extended jet is at least 0.25 pc in length and has a collimation factor of $\sim$ 10, which may be associated with a binary system within the central cluster, resolved for the first time here. This outflow is found to be episodic; probably occurring or getting enhanced during the periastron passage of the binary. We also find that the variable star in the vicinity of the outflow source, which was known as a FU Ori type star, is probably not a FU Ori object. However, it does drive a spectacular outflow and the variability is likely to be related to accretion, when large clouds of gas and dust spiral in towards the central source. Many other convincing accretion-outflow systems and YSO candidates are discovered in the field.Comment: 15 pages, 9 figures, accepted for publication in MNRA

Sublethal Behavioral and Physiological Effects of the Biomedical Bleeding Process on the American Horseshoe Crab, Limulus polyphemus

The hemolymph of the American horseshoe crab, Limulus polyphemus, is harvested from over 500,000 animals annually to produce Limulus amebocyte lysate (LAL), a medically important product used to detect pathogenic bacteria. Declining abundance of spawning Limulus females in heavily harvested regions suggests deleterious effects of this activity, and while mortality rates of the harvest process are known to be 10%–30%, sublethal behavioral and physiological effects are not known. In this study, we determined the impact of the harvest process on locomotion and hemocyanin levels of 28 female horseshoe crabs. While mortality rates after bleeding (18%) were similar to previous studies, we found significant decreases in the linear and angular velocity of freely moving animals, as well as changes in their activity levels and expression of circatidal behavioral rhythms. Further, we found reductions in hemocyanin levels, which may alter immune function and cuticle integrity. These previously unrecognized behavioral and physiological deficits suggest that the harvest of LAL may decrease female fitness, and thus may contribute to the current population decline